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目的分析2型糖尿病(T2DM)合并颈动脉血管病患者的危险因素。方法选取T2DM合并颈动脉血管病患者30例作为试验组,同时选择单纯T2DM患者30例作为对照组,对比观察2组患者年龄、糖尿病病史、吸烟史、高血压史及血糖、血脂水平,分析T2DM合并颈动脉血管病的危险因素。结果常规身体检查和病史调查发现,试验组患者年龄相对较大,糖尿病病程相对较长,吸烟史患者较多,同时,患者多存在高血压病等基础性疾病。试验组患者下丘脑—垂体—性腺(HPG)、FBG、Hb A1c、LDL-C、TG、TC水平均高于对照组,HDL-C、餐后2h C肽(PCP)、空腹C肽(FCP)水平均低于对照组,差异均有统计学意义(P<0.05)。多因素回归分析表明年龄、收缩压(SBP)、2h餐后血糖(2h BG)、胰岛素敏感指数(ISI)、TG是T2DM患者发生颈动脉粥样斑块的独立危险因素(P<0.05)。结论在T2DM患者接受治疗时,应积极预防颈动脉血管病变,接受适当的降压药物治疗,有效控制血压水平,完全禁止吸烟。同时,定时实施血脂、血糖和血压水平的检测。
Objective To analyze the risk factors of type 2 diabetes mellitus (T2DM) with carotid artery disease. Methods Thirty patients with T2DM and carotid artery disease were selected as the experimental group. Thirty patients with T2DM alone were selected as the control group. The age, history of diabetes mellitus, smoking history, history of hypertension and blood glucose and lipid levels were compared between the two groups. T2DM Risk factors for carotid artery disease. Results The results of routine physical examination and medical history found that patients in the test group were relatively older, had a longer duration of diabetes, and had more smoking history. At the same time, patients had more basic diseases such as hypertension. The levels of Hypothalamic-pituitary-gonadal (HPG), FBG, Hb A1c, LDL-C, TG and TC in the experimental group were significantly higher than those in the control group, HDL-C, postprandial 2h C peptide, ) Levels were lower than the control group, the difference was statistically significant (P <0.05). Multivariate regression analysis showed that age, systolic blood pressure (SBP), 2h postprandial blood glucose (2h BG), insulin sensitivity index (ISI) and TG were independent risk factors of carotid plaque in T2DM patients (P <0.05). Conclusions In the treatment of T2DM patients, carotid artery disease should be actively prevented and appropriate antihypertensive drugs should be taken to effectively control the blood pressure level and to ban smoking completely. At the same time, regular implementation of blood lipids, blood glucose and blood pressure levels of detection.