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目的探讨输血传播病毒(TTV)在新疆体检健康和HBV携带儿童中的感染情况,评价TTV的致病性。方法采用套式PCR方法,对230例体检儿童(HBsAg阴性儿童160例,HBV携带儿童70例)血清进行TTV-DNA检测。结果体检儿童230例中共检出40例TTV-DNA阳性,检出率为17.4%.其中HBV阴性健康儿童TTV-DNA阳性22例(13.7%),HBV携带儿童TTV-DNA阳性18例(25.7%),两组比较有显著差异(P<0.05)。结论新疆儿童中存在TTV感染,HBV携带儿童中TTV感染率较高。
Objective To investigate the infection of transfusion transmitted virus (TTV) in health check-up and HBV-carrying children in Xinjiang and to evaluate the pathogenicity of TTV. Methods The nested PCR method was used to detect the serum TTV-DNA in 230 children (160 children with HBsAg-negative and 70 children with HBV). Results The positive rate of TTV-DNA in 230 cases was 17.4% (230 cases), of which 22 (13.7%) were TTV-DNA positive in HBV-negative healthy children and 18 (25.7% ), There was significant difference between the two groups (P <0.05). Conclusion TTV infection exists in Xinjiang children, and the prevalence of TTV infection in HBV-bearing children is high.