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目的探讨宫颈环切术(LEEP术)治疗宫颈上皮内瘤变(CIN)临床疗效影响因素。方法 70例CIN患者均采用LEEP术治疗,治疗后对患者随访1年,根据患者是否复发分为复发组(14例)和未复发组(56例),对两组患者相关临床资料行单因素和多因素Logistic回归分析,探究影响LEEP术治疗CIN疗效危险因素。结果 70例患者治疗后随访1年,56例治愈,治愈率为80.00%;14例复发,复发率为20.00%。单因素分析得出,两组患者在年龄、吸烟史、HPV感染史、手术切缘病理结果、病理分级、病变范围、是否累及腺体方面比较差异有统计学意义(P<0.05)。多因素分析得出,年龄、吸烟、HPV感染、手术切缘病理阳性、病理分级、病变范围及累及腺体均为影响LEEP术治疗CIN疗效危险因素。结论LEEP术治疗CIN具有显著临床疗效,影响其疗效危险因素较多,包括年龄、吸烟、HPV感染、手术切缘病理阳性、病理分级、病变范围及累及腺体等,临床中针对合并高危因素患者应予以治疗和干预,以提高临床临床疗效,降低复发率。
Objective To investigate the influencing factors of clinical efficacy of cervical ring closure (LEEP) in the treatment of cervical intraepithelial neoplasia (CIN). Methods Seventy patients with CIN were treated with LEEP. After treatment, the patients were followed up for 1 year. According to the recurrence of the patients, the patients were divided into recurrent group (n = 14) and non-recurrent group (n = 56) And multivariate Logistic regression analysis to explore the impact of LEEP treatment of CIN risk factors. Results One hundred and seventy patients were followed up for one year, 56 patients were cured, the cure rate was 80.00%; 14 patients relapsed, the recurrence rate was 20.00%. Univariate analysis showed that there was significant difference between the two groups in terms of age, smoking history, HPV infection, surgical margins, pathological grade, extent of lesions and whether the glands were involved (P <0.05). Multivariate analysis showed that age, smoking, HPV infection, positive margins of surgical margins, pathological grade, extent of lesions and involvement of glands were the risk factors for the efficacy of LEEP in the treatment of CIN. CONCLUSION: The clinical efficacy of LEEP in the treatment of CIN has significant clinical effect, which affects many risk factors of treatment, including age, smoking, HPV infection, positive margins of surgical margins, pathological grade, extent of lesions and involvement of glands. In patients with high risk factors Should be treated and interventions to improve clinical clinical efficacy and reduce the recurrence rate.