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目的研究铅接触工人的ALAD基因多态性与铅内暴露剂量之间的关系。方法采集铅接触组工人221人和对照组91人的外周静脉血和尿样,检测血铅(PbB)、尿铅(PbU)、血浆铅(PbP)、血清铅(PbS)和锌原卟啉(ZPP)浓度以及ALAD基因分型。结果铅接触组工人平均PbB、PbU、PbP、PbS、ZPP均高于对照组(P<0.05)。其中PbB、PbP、PbU、ZPP与车间铅浓度呈线性相关(P<0.05)。两组312名观察对象ALAD基因分型属ALAD1-2型共18人,其PbB、PbP、ZPP均值高于配对的18名ALAD1-1的对象(P<0.05)。结论在相同的职业外暴露环境下,ALAD2基因携带者能够增加个体的铅负荷水平,并可能对血液系统的毒性产生影响。
Objective To investigate the association between ALAD gene polymorphism and lead exposure dose in lead exposed workers. Methods Peripheral venous blood and urine samples were collected from 221 workers in the lead exposure group and 91 patients in the control group. PbB, PbU, PbS and Zn protoporphyrin (ZPP) concentration and ALAD genotyping. Results The PbB, PbU, PbP, PbS and ZPP in lead exposure group were higher than those in control group (P <0.05). PbB, PbP, PbU and ZPP were linearly correlated with lead concentration (P <0.05). A total of 312 ALAD genotypes from 312 subjects in both groups were found, with a mean of PbB, PbP and ZPP of 18 ALAD1-1 (P <0.05). Conclusion In the same occupational exposures, carriers of ALAD2 can increase individual lead levels and may have an impact on the toxicity of the blood system.