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目的:观察金黄散外敷联合吲哚美辛治疗急性痛风性关节炎(AGA)的临床疗效和安全性。方法:58例初发AGA患者随机分为两组。对照组给予吲哚美辛治疗,观察组在对照组基础上外敷金黄散。两组疗程均为7 d。观察两组患者的临床疗效、关节症状改善和实验室指标恢复情况及药品不良反应。结果:观察组总有效率为93.10%,明显高于对照组的72.41%(P<0.05)。总体疗效比较,观察组优于对照组(P<0.01)。治疗后,两组患者的关节疼痛、肿胀和活动受限评分及红细胞沉降率(ESR)、白细胞计数(WBC)和血尿酸(BUA)水平均较治疗前下降(P<0.01);且观察组患者症状评分及实验室指标水平均优于对照组(P<0.05和P<0.01)。两组药品不良反应症状均较轻微,发生率差异无统计学意义(P>0.05)。结论:金黄散外敷联合吲哚美辛治疗AGA能有效改善关节症状,降低血尿酸及炎症指标水平,疗效显著。
Objective: To observe the clinical efficacy and safety of golden powder combined with indomethacin in the treatment of acute gouty arthritis (AGA). Methods: 58 patients with newly diagnosed AGA were randomly divided into two groups. The control group was treated with indomethacin, and the observation group was treated with golden powder on the basis of the control group. The two courses of treatment were 7 d. To observe the clinical efficacy of two groups of patients, the improvement of joint symptoms and laboratory indicators of recovery and adverse drug reactions. Results: The total effective rate in the observation group was 93.10%, which was significantly higher than that in the control group (72.41%, P <0.05). The overall curative effect was better in the observation group than in the control group (P <0.01). After treatment, the joint pain, swelling and activity-restricted scores and erythrocyte sedimentation rate (ESR), white blood cell count (WBC) and serum creatinine (BUA) levels in both groups were significantly lower than those before treatment (P <0.01) Patients’ symptom scores and laboratory indexes were better than those of the control group (P <0.05 and P <0.01). Two groups of adverse drug reactions were mild symptoms, the incidence was no significant difference (P> 0.05). Conclusion: The combination of Jinshuanghuang topical application with indomethacin AGA can effectively improve the symptoms of joint and reduce the levels of serum uric acid and inflammation, with a significant curative effect.