目前肠道蠕虫病仍是我国广大农村中的常见病,而且患者往往同时感染多种蠕虫。为了提高防治肠道蠕虫病的效果,需要不断探索研究广谱、高效、低毒的新抗蠕虫药。70年代初甲苯咪唑的问世,是肠蠕虫病治疗上一大进展,它对常见肠道线虫如蛔虫、钩虫、鞭虫、蛲虫以及绦虫均有作用。近年来又合成了许多苯骈咪唑类的衍生物,丙硫咪唑即是其中比较满意又具有发展前途的一种。 At present, intestinal helminth disease is still a common disease in vast rural areas of China, and patients often infect many kinds of worms at the same time. In order to improve the effectiveness of prevention and treatment of intestinal helminthiasis, we need to constantly explore new broad-spectrum, high-efficiency and low-toxicity new anthelmintic drugs. The advent of mebendazole in the early 1970s is a great advance in the treatment of intestinal worms. It has effects on common intestinal nematodes such as roundworms, hookworms, whipworms, pinworms and tapeworms. In recent years, many derivatives of benzodiazepines have been synthesized, and albendazole is one of the more satisfactory and promising ones.