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100年来,在皮肤病学和免疫学上都对免疫性炎症反应进行了研究。直到35年前,所有关于迟发性过敏和接触变应性的认识都是通过诱发和测定皮肤的免疫反应而获得的。Landsteiner等用腹腔渗出液中活的细胞成功地转移迟发性过敏,证明这种过敏性是由淋巴样细胞中介的。此后,迟发性皮肤过敏反应的研究就成为研究淋巴细胞间和淋巴细胞与皮肤间的互相作用的一种重要方法。本世纪初,Arthus现象已成为由抗体引起的即刻型过敏反应的模型。另一种皮肤的抗原抗体反应是IgE抗体与抗原结合引起的风团和红晕——皮肤类过敏性休克。
For 100 years, immunological inflammatory responses have been studied dermatologically and immunologically. Until 35 years ago, all awareness of delayed allergies and contact allergies was obtained by inducing and measuring the skin’s immune response. Landsteiner and other cells in the peritoneal exudate in the successful transfer of delayed hypersensitivity, prove that this allergy is mediated by lymphoid cells. Since then, the study of delayed-onset skin anaphylaxis has become an important method of studying the interplay between lymphocytes and lymphocytes and the skin. At the beginning of this century, the Arthus phenomenon has become a model of an immediate allergic reaction caused by antibodies. Another type of skin antigen-antibody reaction is the combination of IgE antibodies and antigen-induced wheal and flush - skin-type anaphylactic shock.