颌面部的创伤、炎症、肿瘤、先天性畸形等均可造成牙齿、牙周组织、颌骨等口腔颌面部组织器官的缺损。现有的修复手段均存在一定的局限性,难以完全满足临床需要。1995年,Baum[1]首次描述了基因治疗在口腔领域的应用前景。十六年来,随着分子生物学、基因重组技术、再生生物学等基础学 Maxillofacial trauma, inflammation, cancer, congenital malformations can cause teeth, periodontal tissue, jaw and other oral and maxillofacial tissue defects. Existing repair methods have some limitations, it is difficult to fully meet the clinical needs. In 1995, Baum [1] first described the prospect of gene therapy in the oral cavity. Sixteen years, with the molecular biology, gene recombination technology, regenerative biology and other basic science