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目的:探讨分析卡培他滨维持化疗方法治疗晚期胃癌以及术后复发转移胃癌的实际临床效果以及应用安全性。方法:选取2012年10月1日-2013年10月1日在我院行化疗治疗后体征稳定的晚期以及术后复发转移胃癌患者80例,按照随机原则将其分为对照组和观察组。给予对照组40例患者常规化疗六周期,观察组40例患者则在此基础上加用卡培他滨维持化疗三周期治疗。分别统计两组患者的治疗效果以及治疗过程中不良反应发生率。所有实验数据均使用SPSS18.0软件进行统计和分析。结果:对照组患者总有效率为25.0%,显著低于观察组42.5%,两者差异比较具有统计学意义(P<0.05)。观察组不良反应发生率为42.5%,对照组不良反应发生率为40.0%,两者比较不具有显著性差异(P>0.05)。结论:卡培他滨维持化疗治疗方法应用于具有稳定生命体征的晚期胃癌以及术后复发转移胃癌较传统对症治疗方法能够取得更为满意的治疗效果,且不会产生严重的毒副作用反应,值得在临床上进一步推广应用。
Objective: To investigate the actual clinical effect and application safety of capecitabine in maintenance chemotherapy for advanced gastric cancer and recurrence and metastasis of gastric cancer. Methods: From October 1, 2012 to October 1, 2013, 80 patients with advanced gastric cancer who had stable signs and postoperative recurrence and metastasis after chemotherapy were selected and divided into control group and observation group according to random principle. Forty patients in the control group were given six cycles of conventional chemotherapy. Forty patients in the observation group were treated with capecitabine for three cycles of maintenance chemotherapy. The treatment effect of two groups of patients and the incidence of adverse reactions in the course of treatment were respectively counted. All experimental data were used SPSS18.0 software for statistical and analysis. Results: The total effective rate of the control group was 25.0%, which was significantly lower than that of the observation group (42.5%). The difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 42.5%, and the incidence of adverse reactions in the control group was 40.0%. There was no significant difference between the two groups (P> 0.05). CONCLUSIONS: Capecitabine can be used to treat advanced gastric cancer with stable vital signs and postoperative recurrence and metastasis of gastric cancer, which can achieve more satisfactory therapeutic effect than traditional symptomatic treatment without serious toxic and side effects. It is worthwhile To further promote the clinical application.