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[目的]探讨依托咪酯复合地佐辛静脉麻醉在老年患者结肠镜检查的疗效。[方法]选择择期行结肠镜检查老年患者60例，分为三组（ n＝20）：依托咪酯复合地佐辛静脉麻醉组（A组），丙泊酚复合芬太尼静脉麻醉组（B组）和生理盐水对照组（C组），记录三组患者给药前（T0），插镜时（T1），结肠镜过乙状结肠（T2）、脾曲（T3）、肝曲（T4）时的平均动脉压（MAP）、心率（HR）和脉搏血氧饱和度（SpO2）；记录三组患者检查时间、苏醒时间、不适度视觉模拟评分（VAS）、重复检查的依从性评分和术中知晓情况。[结果]60例患者均顺利完成结肠镜检查。A组和B组的检查时间、苏醒时间，术后不适度VAS评分和重复检查的依从性评分均低于C组（ P ＜0．05），但A组和B组之间比较差异无统计学意义（ P ＞0．05）。C组T2、T3和T4时的MAP和HR较T0时升高（ P ＜0．05）；B组T2、T3和T4时的MAP和 HR较T0时降低（ P＜0．05）；A组各时点的MAP和 HR比较差异无统计学意义；与C组比较，A组和B组T2、T3和T4时的MAP和HR均降低（ P ＜0．05）。三组组间和组内脉搏血氧饱和度比较差异均无统计学意义（ P ＞0．05）。A 组和 B组患者均无术中知晓情况，C 组患者检查过程均知晓。[结论]依托咪酯复合地佐辛静脉麻醉可安全有效地用于老年患者结肠镜检查，且患者循环稳定，无明显呼吸抑制。“,”[Objective] To explore the efficacy of intravenous anesthesia with etomidate and dezocine for colonoscopy in elderly patients .[Methods]Sixty ASA Ⅰ ~ Ⅲ elderly patients undergoing elective colonoscopy were randomly divided into etomidate combined with dezocine intravenous anesthesia group (group A ,n=20) ,propofol combined with fentanyl intravenous anesthesia group(group B ,n=20) and normal saline control group(group C ,n=20) .The mean arterial pressure(MAP) ,heart rate(HR) and pulse oxygen saturation(SpO2 ) in 3 groups before administration (T0 ) ,at the beginning of entering the colonoscope(T1 ) ,the colonoscope to the sigmoid colon(T2 ) , to the splenic flexure(T3 ) and hepatic flexure of colon(T4 ) were recorded .The examination time ,the recovery time ,unfitness visual analogue scales(VAS) ,the compliance of repeat examination and intraoperative awareness of 3 groups were recorded .[Results] All 60 patients completed colonoscopy successfully .The examination time ,re-covery time ,postoperative unfitness VAS score and the compliance of repeat examination in group A and group B were lower than those in group C( P 0 .05) .Compared with T0 ,MAP and HR in group C at T2 ,T3 and T4 increased( P<0 .05) ,but those in group B at T2 ,T3 and T4 decreased( P<0 .05) ,and there was significant different in MAP and HR in group A at each time .Compared with group C ,MAP and HR in group A and group B at T2 ,T3 and T4 decreased( P 0 .05) .There was no awareness during colonoscopy in group A and B .Patients in group C had awareness during colonoscopy .[Conclusion]Combined Intravenous anesthesia of etomidate combined with dezocine for colonoscopy in elderly pa-tients is safe and effective ,and can maintain stable hemodynamics without obvious respiratory depression .