基质金属蛋白酶(matrix metalloproteinase,MMP)是体内重要的水解酶之一,几乎能降解细胞外基质(extracellular matrix,ECM)的所有成分;基质金属蛋白酶组织抑制因子(tissue inhibitor of metalloproteinasas,TIMPs)是MMPs的内源性抑制系统。近年来发现,MMPs/TIMPs调节失衡与肝纤维化的关系密切,可从多方面影响肝纤维化的形成。通过干扰MMPs与TIMPs基因的表达,研究肝纤维化的发病机制和药物治疗是有希望的途径。 Matrix metalloproteinase (MMP) is one of the most important hydrolases in the body and can degrade almost all components of extracellular matrix (ECM). Tissue inhibitor of metalloproteinases (TIMPs) Endogenous inhibitory system. In recent years, it has been found that the imbalance of MMPs / TIMPs is closely related to liver fibrosis, which may affect the formation of hepatic fibrosis in many aspects. By interfering with the expression of MMPs and TIMPs, it is a promising way to study the pathogenesis of hepatic fibrosis and drug therapy.