工人在再次接触有机粉尘后常常对这些粉尘产生免疫反应。例如农场工人中的农民肺,纺织工人中的棉屑沉着病等。在煤矿工人中也常常发现有各种免疫学上的异常,例如,肺-反应抗体和胶原-反应抗体已得到证明。另外,在伴有类风湿性关节炎的煤矿工人中有特异的肺结节。煤矿工人中类风湿因子增高、补体滴度降低、血清中和分泌液中 IgA 增高,和偶尔在肺结节中测得球蛋白都提示吸入煤尘与免疫反 Workers are often immune to these dusts after re-exposure to organic dust. Such as farmer lungs among farm workers and cotton swarms in textile workers. A variety of immunological abnormalities are also commonly found in coal miners. For example, lung-reactive antibodies and collagen-reactive antibodies have been demonstrated. In addition, there are specific pulmonary nodules among coal miners associated with rheumatoid arthritis. Increased rheumatoid factor in coal miners, decreased complement titer, increased IgA in serum and secretions, and occasional detection of globulin in lung nodules are indicative of inhalation of coal dust and immunodeficiency