本研究分别利用体内外实验的方法观察了微量元素锌、硒、锰、镍在链脲佐菌素（ＳＴＺ）的作用下对离体胰腺胰岛分泌功能和实验性糖尿病（ＤＭ）大鼠血糖、胰岛素水平的影响，以及和自由基的关系。结果表明，以上微量元素不仅可以降低血糖，具有胰岛素样作用，而且对胰岛的结构和功能有良好的影响。说明微量元素对胰岛β细胞具有保护作用，这种保护作用可能是通过提高自由基清除系统的活性而实现的。 In this study, the effects of streptozotocin (STZ) on insulin secretion in pancreatic islets and the blood glucose, blood glucose, The effect of insulin levels, as well as the relationship with free radicals. The results showed that the above trace elements not only can lower blood glucose, insulin-like effect, but also has a good effect on the structure and function of islets. This shows that trace elements have a protective effect on pancreatic β-cells, and this protective effect may be achieved by increasing the activity of free radical scavenging system.