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目的 :探讨肝硬化患者血浆一氧化氮 (NO)、内毒素和肿瘤坏死因子 - α(TNF- α)的变化及其意义。方法 :用比色法、鲎试验定量检验法及 EL ISA法分别测定 5 6例肝硬化患者血浆的 NO、内毒素及 TNF- α。结果 :肝硬化患者血浆 NO、内毒素及 TNF- α的含量均显著升高 ,肝功能越差 ,升高越明显 ;NO与内毒素及 TNF- α水平显著正相关 ,NO与门脾静脉宽度呈显著正相关。结论 :肝硬化时 ,NO的合成增加 ,且与内毒素、 TNF- α诱导有关 ;NO与肝硬化门脉高压形成的关系密切。
Objective: To investigate the changes of plasma nitric oxide (NO), endotoxin and tumor necrosis factor - α (TNF - α) in patients with liver cirrhosis and their significance. Methods: The contents of NO, endotoxin and TNF-α in plasma of 56 patients with cirrhosis were measured by colorimetry, 鲎 test and ELISA. Results: The levels of plasma NO, endotoxin and TNF-α in patients with cirrhosis were significantly increased, the worse the liver function was, and the more obvious the increase was. NO was positively correlated with the levels of endotoxin and TNF- There was a significant positive correlation. Conclusion: The synthesis of NO increased in cirrhotic rats, and was related to the induction of endotoxin and TNF-α. NO was closely related to the formation of portal hypertension in patients with cirrhosis.