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目的 :观察眼伤宁口服液对家兔巩膜切口愈合过程的影响。方法 :67只家兔( 1 3 4只眼 )随机分为阴性对照组 (羧甲基纤维素组 )、眼伤宁高剂量组、眼伤宁低剂量组、阳性对照组 (消炎痛组 )。利用HE、Masson染色结合图像分析技术对巩膜切口炎症程度及纤维排序进行观察 ,并定量测量切口肉芽组织细胞数目及肉芽组织体积。结果 :眼伤宁口服液治疗组的巩膜切口炎症程度、肉芽组织细胞数目及肉芽组织体积均明显低于阴性对照组和阳性对照组 ,巩膜纤维排列有序优于阴性对照组和阳性对照组。结论 :眼伤宁口服液能明显减轻巩膜切口炎症反应 ,促进巩膜纤维有序排列 ,减轻巩膜瘢痕形成。
Objective : To observe the effect of Yanshangning oral liquid on scleral incision healing in rabbits. METHODS: Sixty-seven rabbits (134 eyes) were randomly assigned to a negative control group (carboxymethylcellulose group), high dose of ocular trauma, a low dose of ocular trauma, and a positive control (indomethacin group). . Using HE, Masson staining combined with image analysis technology to observe the degree of scleral incision inflammation and fiber sorting, and quantitative measurement of incision granulation tissue cell number and granulation tissue volume. Results: The degree of scleral inflammation, the number of granulation tissue cells and the volume of granulation tissue in the eye injury group were significantly lower than those in the negative control group and the positive control group. The scleral fiber arrangement was better than the negative control group and the positive control group. Conclusion: Yanyanning oral liquid can significantly reduce the inflammatory reaction of scleral incision, promote the orderly arrangement of scleral fibers, and reduce the formation of scleral scars.