Objectives To evaluate the effectiveness of firebird stent for the treatment of coronary de novo lesion compared with cypher stent.Methods Ninety-one consecutive patients with 156 lesions who underwent coronary cypher (n = 68lesions) and firebird (n = 88 lesions) implantation,quantitative coronary angiography ( QCA ) was performed at the time of stent implantation and subsequently at 8 months post-stenting. Small vessel disease was defined as ≤2.5 mm of reference vessel diameter measured by QCA. Major adverse cardiac events (MACE) including death, thrombosis,nonfatal myocardial infarction and target lesion revascularization (TLR) were compared between the two groups. Results Baseline clinical characteristics and angiographic parameters were similar between the two groups. Seven-month angiographic follow-up, the late loss was not different between the two groups (0.14 ± 0.38 mm vs 0.13 ± 0.17 mm, P ＞ 0.05).Similarly, overall thrombosis rate were similar in both groups (1.5% vs 1.1%, P ＞ 0.05). However, in-stent restenosis as well as in-segment restenosis rate were significantly higher in cypher group than that in firebird group (4.4% vs 0% and 19.1% vs 3.4%,P = 0.047 and P = 0.001 respectively). TLR was also higher in the cypher group (10.3% vs 2.3%, P =0.033) compared with firebird group. Conclusions In this small sample size, non-randomized study, the data indicated that implantation of firebird stent for the treatment of small coronary lesion showed more favorable results in respective of restenosis compared with cypher stent implantation. A multi-center, largesample size, randomized study, therefore, may be warranted.