目的统计分析乙型肝炎HBs Ag阳性者的血清学模式并探讨其临床意义,为进一步预防与控制乙型肝炎提供科学依据。方法回顾性分析2008年-2013年在南京市第二医院检测的24 737例HBs Ag阳性者的乙肝两对半模式。结果 24 737例HBs Ag阳性者共存在13种血清学阳性模式,主要为“1、4、5”和“1、3、5”阳性模式,分别占50.17%(12 410/24 737)和40.55%(10 030/24 737)。其他>1%的阳性模式有4种,分别为“1、3、4、5”、“1、5”、“1、2、3、5”、“1、2、4、5”阳性模式,依次占2.87%、2.11%、1.77%、1.61%,其他7种低频模式检出率为0.01%~0.25%。“1、3、5”阳性模式在1岁~10岁、11岁~20岁、21岁~30岁3个年龄组占主要比例并随年龄增长所占比例逐渐降低,“1、4、5”阳性模式在31岁~40岁、41岁~50岁、51岁~60岁、61岁以上年龄组占主要比例并随年龄增长所占比例逐渐增高。结论年龄是影响HBe Ag/HBe Ab血清转换的因素,对40岁以上“1、3、5”阳性模式人群应积极治疗,并增加肝硬化及肝癌实验室相关指标监测。 Objective To analyze and analyze the serological patterns of HBsAg-positive hepatitis B patients and to investigate its clinical significance, so as to provide a scientific basis for further prevention and control of hepatitis B. Methods A retrospective analysis of 24 737 HBsAg-positive hepatitis B patients in the Second Hospital of Nanjing from 2008 to 2013 was performed in two-and-a-half pairs. Results There were 13 seropositive positive patterns in 24 737 HBs Ag positives, mainly including “1,4,5” and “1,3,5” positive patterns, accounting for 50.17% (12 410/24 737) and 40.55% (10 030/24 737). Other> 1% of the positive mode, there are four, respectively, “1,3,4,5 ”, “1,5 ”, “1,2,3,5 ”, “1,2 , 4,5 ”positive mode, followed by 2.87%, 2.11%, 1.77%, 1.61%, the other seven kinds of low-frequency mode detection rate of 0.01% to 0.25%. “1,3,5 ” positive model in the age of 1 to 10 years old, 11 years old to 20 years old, 21 years old to 30 years old three age groups accounted for the main proportion and gradually reduce the proportion of increasing age, “ 4,5 ”positive model in 31 years old to 40 years old, 41 years old to 50 years old, 51 years old to 60 years old, 61 years of age group accounted for the main proportion and gradually increased with age. Conclusions Age is the factor affecting the seroconversion of HBe Ag / HBe Ab. It should be actively treated in the population over 40 years old with “1,3,5” positive mode and to monitor the related indexes of liver cirrhosis and liver cancer laboratory.