骨桥蛋白是最早从骨基质分离出的一种富含唾液酸的磷酸化糖蛋白，广泛存在于多种器官组织中，可促进细胞的粘附，调节矿化组织的形成与重塑（ｒｅｍｏｄｅｌｉｎｇ） ，影响细胞的信号转导。与泌尿系结石的形成、机体免疫及感染、肿瘤的发生发展有密切的关系。骨桥蛋白在胃肠及胆囊上皮的分布及亚细胞结构定位研究较多，与消化系疾病的关系引起了人们的重视。 Osteopontin, a sialic acid-rich phosphorylated glycoprotein isolated from the bone matrix, is widely found in many organs and tissues, promotes cell adhesion, regulates the formation and remodeling of mineralized tissue ), Affecting cell signaling. With the formation of urinary stones, immune and infection, the occurrence and development of tumors are closely related. Osteopontin in the gastrointestinal and gallbladder epithelial distribution and subcellular localization of more research, and the relationship between gastrointestinal diseases has aroused people’s attention.