目的观察健脾通腑泄浊针法对高脂血症小鼠血脂及血管内皮保护功能的影响。方法采用高脂饮食饲料喂养制备高脂血症小鼠模型。造模成功后,电针组针刺丰隆、曲池、三阴交穴,在双侧丰隆、曲池穴加用韩式电针仪,以灌服辛伐他汀作为对照组。测定血清三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、内皮素(ET)、一氧化氮(NO)含量。结果第15天模型组小鼠血清TG、TC、LDL-C均高于正常组,HDL-C含量低于正常组(P<0.01或P<0.05),提示造模成功。健脾通腑泄浊针法针刺结束后,高脂血症小鼠血清TG、TC、LDL-C、ET含量降低,HDL-C、NO含量提高。结论健脾通腑泄浊针法具有较好的调节血脂代谢和保护血管内皮功能的作用。 Objective To observe the effects of Jianpi Tongxu Xiezhu acupuncture on blood lipid and vascular endothelium protective function in mice with hyperlipidemia. Methods The hyperlipidemia mouse model was prepared by feeding with high-fat diet. After successful modeling, acupuncture at Honglong, Quchi and Sanyinjiao acupuncture points in acupuncture treatment group were given Korean electric acupuncture instrument on both sides of Fenglong and Quchi acupoints to simvastatin as a control group. Serum triglyceride (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), endothelin (ET) and nitric oxide (NO) Results The serum TG, TC and LDL-C in the model group were higher than those in the normal group on the 15th day, and the content of HDL-C was lower in the model group than in the normal group (P <0.01 or P <0.05). After the acupuncture of spleen and Tong-fu-voiding acupuncture was completed, the levels of serum TG, TC, LDL-C and ET in the mice with hyperlipidemia were decreased and the levels of HDL-C and NO were increased. Conclusion Jianpi Tongfu decoction method has better regulation of blood lipid metabolism and protection of vascular endothelial function.