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氯化钠注射液的含量测定,《中国药典》95版(二部)采用了“银量法。以0.1mol·L~(-1)硝酸银溶液为滴定液,吸附指示剂荧光黄指示终点。我们在实际工作中发现,在对氯化钠注射液进行含量测定时,当被滴溶液的pH值为弱酸性时,终点颜色变化不敏锐,从而影响滴定结果的准确性。如果向被测溶液中加入一定量2.5％硼砂溶液调节pH值使之为弱碱性,这时终点极易观察。现介绍如下。1 药品与试剂 0.9％氯化钠注射液(pH值分别为4.8,5.5,6.3)由贵州天地药业股份有限公司提供;0.1 mol·L~(-1)硝酸银滴定液(按《中国药典》95年版附录配制);2.5％硼砂与2％糊精溶液(实验室配)。
Sodium chloride injection determination, “Chinese Pharmacopoeia” 95 edition (two) using the “silver method.” 0.1 mol·L -1 silver nitrate solution as the titration solution, the indicator of fluorescence yellow indicator endpoint In practice, we found that in the determination of sodium chloride injection, when the pH value of the drop solution is weakly acidic, the endpoint color change is not sharp, thus affecting the accuracy of titration results.If the measured The solution is added a certain amount of 2.5% borax solution to adjust the pH value so that it is weakly alkaline, then the end point is very easy to observe. Are described below .1 drugs and reagents 0.9% sodium chloride injection (pH values were 4.8, 5.5, 6.3) provided by Guizhou Tiandi Pharmaceutical Co., Ltd .; 0.1 mol·L -1 silver nitrate titration solution (prepared according to Appendix of Chinese Pharmacopoeia 95); 2.5% borax and 2% dextrin solution ).