血液系统肿瘤的非随机细胞遗传学改变具有一定的临床和生物学意义。虽然,关于骨髓增生异常综合征(MDS)存在特定的染色体易位的报道很少,但是,某些特定的染色体部位在该病的形成过程中的确起着重要作用。例如,已发现某些MDS中存在5号染色体长臂缺失,即所谓的“5q~-综合征”,5q~-在肿瘤形成过程中的可能作用之一是缺失部位带有“抗癌基因”一如同视网膜母细胞瘤的RB基因。本文报道两例MDS的双倍 Non-random cytogenetic changes in hematological tumors have some clinical and biological significance. Although there are few reports on the presence of specific chromosomal translocations in myelodysplastic syndromes (MDSs), certain chromosomal loci indeed play an important role in the pathogenesis of this disease. For example, it has been found that in some MDS there is a long arm deletion on chromosome 5, the so-called “5q ~ -syndrome.” One of the possible roles of 5q ~ - in tumorigenesis is that the deletion site carries “anti-oncogene” Just like RB gene of retinoblastoma. This article reports doubled MDS in two cases