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目的：探讨发作间期１８Ｆ脱氧葡萄糖（ＦＤＧ）正电子发射断层扫描（ＰＥＴ）和９９ｍＴｃ已撑半胱氨酸（ＥＣＤ）单光子发射断层扫描（ＳＰＥＣＴ）对难治性颞叶癫痫（ＴＬＥ）的定位诊断价值。方法：５３例脑电图（ＥＥＧ）定位明确的难治性ＴＬＥ患者分别行发作间期１８ＦＦＤＧＰＥＴ和９９ｍＴｃＥＣＤＳＰＥＣＴ检查。其中２１例磁共振（ＭＲＩ）显示有结构性病变并与ＥＥＧ定位结果一致。结果：ＭＲＩ异常组均在ＰＥＴ和ＳＰＥＣＴ相应部位出现低代谢和低灌注表现。ＭＲＩ正常组，ＰＥＴ定位准确率为８４％，显著高于ＳＰＥＣＴ的５６％（Ｐ＜００５）。结论：对于无结构性病变的颞叶癫痫，发作间期ＰＥＴ检查有较高的定位诊断价值，ＳＰＥＣＴ的临床意义相对较小。
OBJECTIVE: To investigate the clinical value of 18F deoxyglucose (FDG) positron emission tomography (PET) and 99mTc-epicatechin (ECD) single photon emission tomography (SPECT) in the treatment of refractory temporal lobe epilepsy ) Diagnostic value of the location. Methods: Fifty-three EEG patients with well-defined refractory TLE were examined with 18F-FDG PET and 99mTc-ECSPECT respectively. 21 cases of MRI showed structural lesions and consistent with the results of EEG localization. Results: The abnormal MRI group showed low metabolism and hypoperfusion in the corresponding parts of PET and SPECT. In the normal MRI group, the accuracy of PET localization was 84%, significantly higher than 56% of SPECT (P <005). Conclusion: For temporal lobe epilepsy without structural lesions, interictal PET examination has a higher diagnostic value of location, the clinical significance of SPECT is relatively small.