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目的评价血清胱抑素C(CysC)在妊娠期高血压(GH)早期肾损害中的意义。方法收集39例正常妊娠晚期妇女及23例轻度、25例中度、27例重度妊高征患者血清,以颗粒增强散射比浊法测定CysC;以生化分析法测定尿素氮(BUN)、血肌酐(SCr)、尿酸(UA)含量,并加以比较。结果妊高征患者各指标血清值较正常晚孕者明显增高(P<0.05),其中重度妊高征患者的各指标血清值较轻度、中度妊高征明显增高(P<0.05),轻度、中度妊高征各值相差不明显。胱抑素比血尿酸对重度妊高征有更好的灵敏性。结论胱抑素在重度的妊高征中有明显变化,与其他肾功能指标联合能灵敏反映重度妊高征患者早期肾损害。
Objective To evaluate the significance of serum cystatin C (CysC) in early stage renal damage in gestational hypertension (GH). Methods Thirty-nine women with normal late pregnancy and 23 patients with mild, moderate, and severe pregnancy-induced hypertension were enrolled in this study. CysC was determined by particle-enhanced nephelometry. The levels of blood urea nitrogen (BUN) and blood Creatinine (SCr), uric acid (UA) content, and compared. Results Serum levels of each index of patients with PIH were significantly higher than those of normal pregnancy (P <0.05). Serum values of patients with severe PIH were significantly higher than those of normal pregnancy (P <0.05) Mild, moderate pregnancy-induced hypertension difference between the value is not obvious. Cystatin than uric acid on severe PIH have better sensitivity. Conclusions Cystatin has obvious changes in severe PIH. Combined with other renal function indexes, cystatin can sensitively reflect the early renal damage in patients with severe PIH.