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目的 研究肥胖或超重者与体重正常者餐前、餐后血清肿瘤坏死因子-α(TNF-α)与胰岛素(INS)水平的变化。方法 以体重指数(BMI)≥25为肥胖(或超重)组30例,体重指数<25为正常对照组30例。分别于空腹及馒头(100 g)餐后2h抽取肘静脉血,以放射免疫法测定血清TNF-α、INS的含量。结果 肥胖组空腹、餐后TNF-α水平变化差异无显著性,对照组餐后TNF-α水平较空腹明显升高(P<0.001);肥胖组空腹TNF-α水平较对照组升高(P<0.001);肥胖组、对照组餐后TNF-α水平差异无显著性,但餐后INS水平肥胖组较对照组升高(P<0.01)。结论 肥胖者体内存在INS-TNF-α调节机制失衡,这一平衡失调具有双重作用。
Objective To investigate the changes of serum levels of tumor necrosis factor-α (TNF-α) and insulin (INS) in obese or overweight and normal weight subjects before and after meals. Methods 30 patients with body mass index (BMI) ≥25 were obese (or overweight) and 30 patients with body mass index <25 were normal control group. The elbow venous blood was drawn 2 hours after fasting and steamed bread (100 g) respectively, and the levels of serum TNF-α and INS were measured by radioimmunoassay. Results There was no significant difference in fasting and postprandial levels of TNF-α in obese group. The level of TNF-α in postprandial blood of control group was significantly higher than that in fasting group (P <0.001) <0.001). There was no significant difference in postprandial TNF-αlevel between obesity group and control group, but postprandial INS level obesity group was higher than that of control group (P <0.01). Conclusion There is an imbalance in the regulation mechanism of INS-TNF-α in obese subjects. This imbalance has a dual role.