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目的：探讨心血管内科医院感染患者的病原学特点，为临床心血管内科防治医院感染、加强对医院感染的控制提供可靠的依据。方法回顾性分析2011年5月－2013年5月心血管内科住院1132例患者的临床资料，对于确诊为医院感染的患者，根据病原学检测报告，对心内科医院感染患者的病原菌分布及其耐药性特点进行分析。结果1132例心血管内科住院患者中发生医院感染98例、119例次，感染率8．66％、例次感染率10．51％；感染部位以上呼吸道为主占48．74％；检出病原菌共134株，其中革兰阴性菌84株占62．69％，革兰阳性菌39株占29．10％，真菌11株占8．21％；大肠埃希菌对美罗培南、亚胺培南敏感率分别为100．00％、96．55％，对头孢噻肟、头孢曲松及哌拉西林100．00％耐药；金黄色葡萄球菌对利奈唑胺、万古霉素的敏感率最高，均为100．00％，而对苯唑西林、青霉素G则100．00％耐药。结论心血管内科患者医院感染其感染部位主要以呼吸道为主，其病原菌主要以革兰阴性杆菌为主，且病原菌耐药性较高，治疗应严格坚持细菌培养以及药敏试验的原则，针对性地使用抗菌药物。“,”OBJECTIVE To explore the etiological characteristics of nosocomial infections in the patients of cardio‐vascular medicine department so as to provide reliable basis for prevention and control of the nosocomial infections in the cardiovascular medicine department .METHODS The clinical data of 1 132 patients who were hospitalized the cardiovascular medicine department from May 2011 to May 2013 were retrospectively analyzed .For the patients with confirmed nosocomial infections ,on the basis of etiological examination report ,the distribution and drug re‐sistance of the pathogens causing nosocomial infections in the department of internal medicine were observed . RESULTS The nosocomial infections occurred in 98 of 1 132 hospitalized patients (119 case‐times ) of the cardio‐vascular medicine department with the infection rate of 8 .66% and the case‐time infection rate of 10 .51% ,among whom the patients with upper respiratory tract infections accounted for 48 .74% .A total of 134 strains of patho‐gens have been isolated ,including 84 (62 .69% ) strains of gram‐negative bacteria ,39 (29 .10% ) strains of gram‐positive bacteria ,and 11 (8 .21% ) strains of fungi .The drug susceptibility rates of the Escherichia coli to mero‐penem and imipenem were 100 .00% and 96 .55% ,respectively ,the drug resistance rates to cefotaxime ,ceftriax‐one ,and piperacillin were 100 .00% .The drug susceptibility rates of the Staphylococcus aureus to linezolid and vancomycin were 100 .00% , while the drug resistance rates to oxacillin and penicillin G were 100 .00% . CONCLUSIONS The respiratory tract is the predominant infection site of the patients in the cardiovascular medicine department .The gram‐negative bacilli are dominant among the pathogens ,which are highly drug‐resistant .It is necessary to adhere to the bacterial culture as well as the drug susceptibility testing so as to reasonably use antibi‐o tics .