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苄基异喹啉类化合物具有较强的拮抗钙调素(Calmodulin,Cam)的活性,测定这类化合物HPLC参数LogK′作为疏水参数与抑制钙调素的活性进行相关分析,结果表明活性随化合物亲脂性的增大而升高,二者较符合抛物线关系。
Benzyl isoquinolines have strong antagonistic activity against calmodulin (Cam). The correlation analysis of HPLC parameters LogK ’of these compounds as hydrophobic parameter and inhibition of calmodulin activity showed that the activities of compounds with compound Lipophilic increased and increased, the two are more in line with the parabolic relationship.