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代谢途径及细胞内杀伤机制寄生虫代谢途径的研究目的在于确定可用于进行化疗干扰的独特的代谢途径——这种方法在细菌感染方面已经使用了50年。最早使用的是磺胺类药物,如嘧啶类(DNA的基本成分)。在锥虫体内可通过其体内的代谢途径自行合成,而这种代谢途径却不存在于其动物宿主的细胞内。在宿主研究方面着重于确定细胞内与杀死寄生虫机制有关的代谢途径,希望找到加强宿主防御机制的方法, 如氧的激活可能对细胞内杀死原虫起着重要作用。一、寄生虫代谢途径 Akin rimisi研究了非洲锥虫的新陈代谢与分子生物学。其目的在于确定锥虫代谢的一些异常特性,使用了从感染动物分离出来的锥虫和体外培养的锥虫。目前,由七个生物化学家组成的科研小组正在从事以下各
Metabolic Pathways and Intracellular Killer Mechanisms The study of parasite metabolic pathways aims to identify unique metabolic pathways that can be used for chemotherapeutic interference - a method that has been in use for 50 years in bacterial infections. The earliest use of sulfa drugs, such as pyrimidines (DNA of the basic components). Trypanosomes can be synthesized by themselves in the body’s metabolic pathways, which are not found in the cells of their animal hosts. In host research, it is important to identify metabolic pathways that are involved in killing the parasite in the cell. We hope to find ways to enhance host defense mechanisms, such as the activation of oxygen, which may play an important role in the killing of protozoa in cells. First, the parasite metabolic pathway Akin rimisi studied African trypanosome metabolism and molecular biology. Its purpose is to identify some abnormalities in trypanosome metabolism, using trypanosomes isolated from infected animals and trypanosomes cultured in vitro. Currently, a research team of seven biochemists is working on the following