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目的探讨甲钴胺与前列地尔注射液联合应用于糖尿病周围神经病变患者的临床疗效和安全性,旨在为规范糖尿病周围神经病变的治疗提供参考依据。方法选择2010年3月至2012年3月在我院治疗的128例并发周围神经病变的糖尿病患者为研究对象,应用随机数字表法将本研究入选患者分为对照组和观察组,对照组患者给予甲钴胺进行治疗,而观察组患者则在上述治疗的基础上加用前列地尔注射液进行治疗,两组患者其他治疗措施相同,观察并比较对照组和观察组患者临床疗效和不良反应发生情况。结果观察组患者治疗总有效率(96.88%)明显高于对照组患者的(89.06%),差异有统计学意义(P<0.05),且对照组和观察组患者在不良反应发生方面差异无统计学意义(P>0.05)。结论甲钴胺与前列地尔注射液联合是治疗糖尿病周围神经病变患者的一种安全可靠的治疗方案,该方案具有临床疗效确切和不良反应少等特点,值得进一步推广。
Objective To investigate the clinical efficacy and safety of mecobalamin in combination with alprostadil for diabetic peripheral neuropathy in order to provide a reference for regulating the treatment of diabetic peripheral neuropathy. Methods A total of 128 diabetic patients with peripheral neuropathy who were treated in our hospital from March 2010 to March 2012 were enrolled in this study. Patients in the control group were divided into control group and observation group by random number table. Given mecobalamin for treatment, while the observation group patients in the above treatment based on the use of alprostadil injection for treatment, the other two groups of patients with the same treatment to observe and compare the clinical efficacy and adverse reactions in the control group and observation group What happened? Results The total effective rate (96.88%) in the observation group was significantly higher than that in the control group (89.06%), the difference was statistically significant (P <0.05), and there was no statistical difference in the incidence of adverse reactions between the control group and the observation group Significance (P> 0.05). Conclusion Mecobalamin combination with alprostadil injection is a safe and reliable treatment for patients with diabetic peripheral neuropathy. The combination of mecobalamin and alprostadil has the characteristics of definite curative effect and few adverse reactions, which is worth further promotion.