In this study, two different designs of liquid metal fast reactor (LMFR) fuel rods wire-wrapped and non-wire-wrapped (bare) are compared with respect to different parameters as a means of considering the optimum fuel design. Nuclear seismic rules require that systems and components that are important for safety must be capable of bearing earthquake effects, and that their integrity and functionality should be guaranteed. Mode shapes, natural frequencies, stresses on cladding, and seismic aspects are considered for comparison using ANSYS. Modal analysis is compared in a vacuum and in lead–bismuth eutectic (LBE) using potential flow theory by considering the added mass effect. A simple and accurate approach is suggested for the determination of the LBE added mass effect and is verified by a manually calculated added mass, which fur-ther proved the usefulness of potential flow theory for the accurate estimation of the added mass effect. The verifi-cation of the hydrodynamic function (τ) over the entire frequency range further validated the finite element method (FEM) modal analysis results. Stresses obtained for fuel rods against different loading combinations revealed that they were within the allowable limits with maximum stress ratios of 0.25 (bare) and 0.74 (wire-wrapped). In order to verify the structural integrity of cladding tubes, stresses along the cladding length were determined during different transients and were also calculated manually for static pressure. The manual calculations could be roughly com-pared with the ANSYS results, and the two showed a close agreement. Contact analysis methodology was selected, and the most appropriate analysis options were suggested for establishing contact between the wire and cladding for the wire-wrapped design grid independence analysis, which proved the accuracy of the results, confirmed the selection of the appropriate procedure, and validated the use of the ANSYS mechanical APDL code for LMFR fuel rod analysis. The results provided detailed insight into the structural design of LMFR fuel rods by considering dif-ferent structural configurations (i.e., bare and wire-wrap-ped) in the seismic loading;this not only provides a FEM procedure for LMFR fuel with complex configuration, but also guides the reference design of LMFR fuel rods.