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2-脱氧葡萄糖(2-Deoxyglucose,2-DG)被证明对多种肿瘤细胞有抑制作用其作为可能的抗肿瘤药物的研究已有近半个世纪一系列的研究显示2-脱氧葡萄糖有较复杂的抗肿瘤机制。除了对糖酵解的抑制,降低细胞内ATP,抑制生长以外,它还抑制寡糖链来干扰肿瘤的糖基化,引起细胞内的未折叠蛋白反应和凋亡,或影响糖基化来抑制相关转录因子。在单独使用时,可激活某些肿瘤的凋亡通路和因子,造成细胞凋亡,尚可影响氧化还原反应,抑制肿瘤生长。联合使用时,它被证实在体外对放化疗有增敏作用,还可减少化疗药物造成的机体损伤动物实验和部分Ⅰ期临床研究,证实2-脱氧葡萄糖具有代谢快、不良反应小的特点但国内对2-脱氧葡萄糖的相关研究以及重视程度尚不足本文回顾了2-脱氧葡萄糖的抗肿瘤机制和研究现状,对其抗肿瘤作用机制的最新进展做简要综述
2-Deoxyglucose (2-DG) has been shown to inhibit various tumor cells. It has been studied for about half a century as a potential antitumor drug. A series of studies have shown that 2-deoxyglucose is more complicated Anti-tumor mechanism. In addition to inhibiting glycolysis, decreasing intracellular ATP, and inhibiting growth, it also inhibits oligosaccharide chains from interfering with tumor glycosylation, causing unfolded protein responses and apoptosis within the cell, or affecting glycosylation to inhibit Related transcription factors. When used alone, can activate some of the tumor’s apoptotic pathways and factors, resulting in apoptosis, can still affect the redox reaction, inhibit tumor growth. When used in combination, it has been shown to sensitize to chemoradiotherapy in vitro and to reduce the body damage caused by chemotherapeutic drugs in animal experiments and part of Phase I clinical studies, confirming that 2-deoxyglucose has the characteristics of fast metabolism and small adverse reactions The domestic research on 2-deoxyglucose and the degree of attention is not enough.This paper reviews the antitumor mechanism and research status of 2-deoxyglucose, and reviews the latest progress of its antitumor mechanism