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目的 :评价保存人羊膜移植手术在眼表结构重建中的临床应用效果。方法 :对 8例不同眼表疾病患者采用低温保存人羊膜进行移植手术以重建眼表结构。其中 1例为眼球严重碱烧伤并发角膜溃疡 ,同时合并角膜缘干细胞严重缺乏 ,1例为假性翼状胬肉并发睑球粘连 ,1例为角膜血管翳伴有角膜上皮长期糜烂 ,4例为复发性翼状胬肉 ,1例为巨大翼状胬肉。结果 :重度碱烧伤并发角膜溃疡 ,同时因角膜缘干细胞严重缺乏 1例 ,术后 3个月羊膜植片全部溶解 ,手术失败。其余 7例均成功再造眼表结构 ,随访 3个月 ,无排异反应 ,植片透明生长 ,手术成功率为 87 5 %。结论 :保存人羊膜移植手术可有效重建眼表疾病的正常眼表结构。对合并角膜缘干细胞严重缺乏的病例 ,应联合角膜缘干细胞移植
OBJECTIVE: To evaluate the clinical effect of preservative amniotic membrane transplantation in ocular surface reconstruction. Methods: Eight patients with different ocular surface disease were treated with cryo-preserved human amniotic membrane to reconstruct ocular surface structure. One case of severe alkali burn with corneal ulcer accompanied by a serious lack of corneal limbal stem cells, 1 case of pseudo-pterygium complicated by symblepharon, corneal epithelium in 1 case with corneal epithelial erosion, 4 cases of recurrence Pterygium, 1 case of giant pterygium. Results: Severe alkali burn combined with corneal ulcer, at the same time due to a serious lack of corneal limbal stem cells in 1 case, 3 months after the amniotic membrane all dissolved, the operation failed. The remaining 7 cases were successfully reconstructed ocular surface structure, followed up for 3 months, no rejection, transparent growth of the graft, the success rate was 87.5%. Conclusion: Amniotic membrane transplantation can effectively reconstruct the normal ocular surface structure of ocular surface disease. For cases of severe combined limbal stem cell deficiency, limbal stem cell transplantation should be combined