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目的观察慢性阻塞性肺疾病(COPD)并心力衰竭患者血清氨基末端B型脑钠肽前体(NT-proBNP)水平变化,探讨其临床意义。方法选取2014年6月—2016年4月武汉市结核病防治所收治的COPD患者55例,根据是否并发心力衰竭分为观察组(并发心力衰竭,n=35)和对照组(未并发心力衰竭,n=20)。比较两组患者血清NT-proBNP水平,并分析血清NT-proBNP水平与心功能的关系。结果观察组患者血清NT-proBNP水平高于对照组(P<0.05)。Spearman秩相关分析结果显示,血清NT-proBNP水平与心功能分级呈正相关(rs=0.867,P<0.05)。结论COPD并心力衰竭患者血清NT-proBNP水平明显升高,可通过检测血清NT-proBNP水平变化评估患者心功能。
Objective To observe the changes of serum levels of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic obstructive pulmonary disease (COPD) and heart failure and to investigate its clinical significance. Methods Fifty-five COPD patients admitted to Wuhan TB Hospital from June 2014 to April 2016 were divided into observation group (with concurrent heart failure, n = 35) and control group (without concurrent heart failure, n = 20). The serum NT-proBNP levels were compared between the two groups, and the relationship between serum NT-proBNP levels and cardiac function was analyzed. Results The level of NT-proBNP in observation group was higher than that in control group (P <0.05). Spearman rank correlation analysis showed that there was a positive correlation between serum NT-proBNP level and cardiac function classification (rs = 0.867, P <0.05). Conclusion Serum NT-proBNP levels are significantly elevated in patients with COPD and heart failure, and their cardiac function can be evaluated by detecting the level of serum NT-proBNP.