环核苷酸(Cyclic Nucleotides CN)是细胞内的“第二信使”,许多激素、神经递质等“第一信使”的作用均通过它实现。癫痫与脑内环核苷酸的关系密切。本文旨在通过测定癫痫病人脑脊液中环核苷酸(cAMP和cGMP)含量的变化来探讨癫痫的病理生理机制。 材料和方法 一般资料 本组44例癫痫均为1987年11月～1988年3月我院神经科门诊的病人,经专科医师根据临床症状、脑电图及其它有关辅助检查确诊,并排除其 Cyclic Nucleotides CN is a “second messenger” in the cell through which many “first messengers” such as hormones and neurotransmitters act. Epilepsy and intracytoplasmic nucleotides are closely related. This article aims to explore the pathophysiological mechanism of epilepsy by measuring the changes of cyclic nucleotide (cAMP and cGMP) in cerebrospinal fluid of patients with epilepsy. Materials and Methods General Information The group of 44 cases of epilepsy are from November 1987 to March 1988 in our hospital neurology clinic patients, the specialist according to clinical symptoms, EEG and other related auxiliary examination confirmed and excluded