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目的探讨P-糖蛋白(P-gp)在软骨肉瘤中的表达及其与肿瘤的发生、发展及预后的关系。方法应用免疫组化S-P法,检测48例软骨肉瘤,20例软骨瘤做对照,对其在软骨肉瘤不同病理分级、预后分组中的表达进行对比分析和相关研究。结果软骨肉瘤组织中P-gp蛋白阳性表达率与软骨瘤相比,差异有显著性(P<0.05)。软骨肉瘤复发组P-gp蛋白的阳性表达率与未复发组相比,差异有显著性(P<0.05)。P-gp蛋白阳性表达率与瘤组织分化程度呈显著负相关(P<0.01),在软骨肉瘤不同组织学分级间P-gp蛋白阳性表达率相比均呈显著性差异(P<0.05)。结论P-gp蛋白的高表达是软骨肉瘤发生、发展及不良预后的重要指标,对临床具有重要的指导意义。
Objective To investigate the expression of P-glycoprotein (P-gp) in chondrosarcoma and its relationship with tumorigenesis, development and prognosis. Methods Immunohistochemical S-P method was used to detect 48 chondrosarcomas and 20 chondromas as controls. The expression of chondrosarcoma in different pathological grades and prognosis groups was compared and analyzed. Results The positive expression rate of P-gp protein in chondrosarcoma was significantly different from that of chondroma (P<0.05). The positive expression rate of P-gp protein in the recurrent chondrosarcoma group was significantly different from that in the non-recurrent group (P<0.05). The positive expression rate of P-gp protein was significantly negatively correlated with the degree of tumor differentiation (P<0.01). The positive expression rate of P-gp protein in different histological grades of chondrosarcoma showed a significant difference (P<0.05). Conclusion The high expression of P-gp protein is an important indicator of the occurrence, development and poor prognosis of chondrosarcoma, and it has important guiding significance for the clinic.