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最近过氧化脂质作为有退行性变化之疾病或老化的原因之一及作为对细胞损伤的可能机制被注意。过氧化脂质的分解,主要在肝脏。已经证明四氯化碳、乙醇中毒和氯仿等麻醉剂引起肝脏的改变,也和生成的过氧化脂质有关。本文以氢过氧化枯稀0.765mg/50g体重注入孵化11天之鸡胚卵黄囊内,再孵化8天,取肝组织测定其中丙二醛(过氧化脂质的分解产物),并作透射电镜观察。实验组表明肝组织内丙二醛量明显多于对照组。电镜下主要是肝细胞核及线粒体的改变。线粒体呈明显之变性变化。一部分肝细胞已呈现坏死之所见。这可以说明肝功能发生障碍,结合肝组织内丙二醛的测定,病变是由过氧化脂质引起的。这对理解某些肝疾病病人血清中,过氧化脂质之升高,提供了形态学基础。肝组织内过氧化脂质之升高,可能由于肝功能障碍,在肝组织内,产生过多的过氧化脂质及肝组织降低了除去过氧化脂质的能力有关。这对于理解某些肝疾病(如酒精性肝中毒,药物性肝中毒等)之发病机理,并及时给以抗氧化剂(如硒及维生素E等),能带来较好的防治效果,理解其机制,都将是有益的。
Lipid peroxidation has recently been one of the reasons for the degenerative diseases or aging and as a possible mechanism for cell damage. Lipid peroxidation, mainly in the liver. It has been shown that anesthetics such as carbon tetrachloride, alcoholism and chloroform cause changes in the liver and are also linked to the formation of lipid peroxides. In this paper, 0.765mg / 50g body weight of heptahydrate hydroperoxide was injected into the yolk sac of chick embryo which was incubated for 11 days, and then incubated for another 8 days. Malondialdehyde (the breakdown product of lipid peroxidation) was taken from the liver tissue for transmission electron microscopy Observed. Experimental group showed that the amount of malondialdehyde in liver tissue was significantly more than the control group. Electron microscopy is mainly changes in liver cell nucleus and mitochondria. Mitochondria showed obvious degeneration changes. Some of the liver cells have shown necrosis. This may indicate an obstacle to liver function, combined with the determination of malondialdehyde in liver tissue, which is caused by lipid peroxidation. This provides a morphological basis for understanding the elevated lipid peroxides in the sera of patients with certain liver diseases. Elevated levels of lipid peroxides in liver tissue may be due to liver dysfunction, excessive production of lipid peroxidation and liver tissue in the liver tissue, reducing the ability to remove peroxidized lipids. This understanding of the pathogenesis of certain liver diseases (such as alcoholic liver poisoning, drug-induced liver toxicity, etc.), and promptly given antioxidants (such as selenium and vitamin E, etc.), can bring better control effect, understanding Mechanisms will be helpful.