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目的探讨经鼻持续气道正压通气(NCPAP)在新生儿急性呼吸衰竭中的疗效。方法对我院NICU的76例新生儿急性呼吸衰竭患儿,在综合治理基础上分为NCPAP治疗组42例,对照组(非NCPAP治疗)34例,监测其治疗前、治疗后1h及24h动脉血气、呼吸频率,同时观察临床不良反应及合并症。结果 NCPAP组与对照组治疗24h后比较,PaO2明显升高(P<0.01),呼吸改善(P<0.01),PaCO2明显降低(P<0.05);NCPAP治疗1、24h后与应用前比较,PaO2明显升高、呼吸及PaCO2明显降低(P<0.01)。NCPAP组平均住院天数与对照组比较明显降低(P<0.05),NCPAP组仅2例需改用气管插管辅助机械通气(CMV),无死亡病例,对照组8例需改用CMV,2例拒绝CMV,,放弃治疗后死亡。结论新生儿急性呼吸衰竭患儿应用NCPAP治疗简便、安全、有效且并发症少,同时减少CMV的应用。
Objective To investigate the efficacy of nasal continuous positive airway pressure (NCPAP) in neonatal acute respiratory failure. Methods A total of 76 neonates with acute respiratory failure (NICU) were divided into NCPAP group (n = 42) and control group (non-NCPAP group), 34 patients were monitored before treatment, 1h and 24h after treatment Blood gas, respiratory rate, at the same time observe the clinical adverse reactions and complications. Results Compared with the control group, PaO2 was significantly increased (P <0.01), respiration was improved (P <0.01) and PaCO2 was significantly decreased (P <0.05). After NCPAP treatment for 1 and 24 hours, Obviously increased, respiration and PaCO2 decreased significantly (P <0.01). The average length of stay in NCPAP group was significantly lower than that in control group (P <0.05). Only 2 patients in NCPAP group needed to be replaced by endotracheal intubation-assisted mechanical ventilation (CMV) without death. In control group, 8 patients needed CMV and 2 patients Reject CMV, give up treatment after death. Conclusion NCPAP in neonates with acute respiratory failure is simple, safe, effective and has fewer complications and reduces the application of CMV.