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目的探讨静脉血栓栓塞(venous thromboembolism,VTE)患者血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素6(Interleukin-6,IL-6)、纤维蛋白原(fibrinogen,Fib)和D-二聚体(D-dimer,D-D)的临床意义及相关性。方法测定152例静脉血栓栓塞患者(病例组)和144例正常对照者(对照组)TNF-αI、L-6、Fib、D-D水平。分析TNF-αI、L-6、Fib和D-D水平变化与VTE的关系,并分析TNF-αI、L-6、Fib和D-D之间的相关性。结果病例组白细胞计数、血小板计数、纤维蛋白原、肌酸激酶、乳酸脱氢酶、碱性磷酸酶、D-二聚体、TNF-αI、L-6均明显升高,与对照组比较,差异有统计学意义(P<0.05)。IL-6、D-D、Fib两两之间具有相关性(r=0.179、0.138、0.261,P<0.05)。结论炎症与VTE密切相关,TNF-α、IL-6、Fib、D-D参与了VTE的发病过程,是VTE的重要危险因素。炎症因子与凝血因子相互作用发挥促凝作用,是VTE发生的可能发病机制之一。
Objective To investigate the changes of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and fibrinogen (Fib) in patients with venous thromboembolism (VTE) And D-dimer (D-dimer, DD) clinical significance and relevance. Methods The levels of TNF-αI, L-6, Fib and D-D in 152 patients with venous thromboembolism (patients) and 144 normal controls (control group) were determined. The relationship between the changes of TNF-αI, L-6, Fib and D-D levels and VTE was analyzed and the correlation between TNF-αI, L-6, Fib and D-D was analyzed. Results The white blood cell count, platelet count, fibrinogen, creatine kinase, lactate dehydrogenase, alkaline phosphatase, D-dimer, TNF-αI and L-6 in the cases were significantly higher than those in the control group The difference was statistically significant (P <0.05). IL-6, D-D and Fib were correlated with each other (r = 0.179,0.138,0.261, P <0.05). Conclusion Inflammation is closely related to VTE. TNF-α, IL-6, Fib and D-D are involved in the pathogenesis of VTE and are important risk factors for VTE. Inflammatory factor and coagulation factor interaction procoagulant effect is one of the possible pathogenesis of VTE.