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目的观察胰岛素泵强化降糖治疗2型糖尿病合并阻塞性睡眠呼吸暂停综合症(OSAS)患者的疗效。方法运用随机数字表法将108例2型糖尿病合并OSAS患者分为强化治疗组和常规治疗组,前者给予胰岛素持续皮下泵入强化治疗,后者给予胰岛素常规皮下注射治疗。治疗前及治疗4周后分别进行多导睡眠仪检查,观察治疗前后2组患者呼吸紊乱指标的变化。结果 2组患者2型糖尿病治疗前,呼吸暂停低通气指数(AHI)、暂停指数、紊乱指数、最长呼吸暂停时间和最低氧饱和度差异无统计学意义(P>0.05),经过4周治疗后,强化治疗组患者在呼吸暂停低通气指数(AHI)、暂停指数、紊乱指数和最低氧饱度上明显好于常规治疗组患者差异有统计学意义(P<0.05),但在最长呼吸暂停时间上差异无统计学意义(P>0.05)。结论胰岛素泵强化降糖治疗能够改善2型糖尿病合并阻塞性睡眠呼吸暂停综合症(OSAS)患者呼吸暂停低通气指数(AHI)、暂停指数、紊乱指数和最低氧饱和度,该治疗方案值得在临床治疗中推广应用。
Objective To observe the effect of insulin pump intensive hypoglycemic therapy on type 2 diabetes mellitus patients with obstructive sleep apnea syndrome (OSAS). Methods A total of 108 patients with type 2 diabetes mellitus and OSAS were divided into intensive treatment group and conventional treatment group by random number table method. The former was given continuous subcutaneous insulin infusion therapy and the latter was given insulin subcutaneous injection. Before treatment and after 4 weeks of treatment, polysomnography was performed to observe the changes of respiratory disorders in both groups before and after treatment. Results Before treatment, type 2 diabetes mellitus patients had no significant difference in apnea hypopnea index (AHI), pause index, disorder index, longest apnea time and lowest oxygen saturation (P> 0.05). After 4 weeks treatment (P <0.05). However, the patients in the intensive treatment group were significantly better than the conventional treatment group in the apnea-hypopnea index (AHI), pause index, disorder index and the lowest oxygen saturation (P <0.05) There was no significant difference in pause time (P> 0.05). Conclusion Insulin pump intensive hypoglycemic treatment can improve apnea hypopnea index (AHI), pause index, disorder index and minimum oxygen saturation in type 2 diabetes mellitus patients with obstructive sleep apnea syndrome (OSAS) Treatment of the promotion and application.