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本文报告采用琼脂糖电泳分析218名健康人(男81例,女137,30—90岁)的血清蛋白组分胆固醇水平,结果:低密度脂蛋白胆固醇(LDL—C)100.2±24.4,极低密度脂蛋白胆固醇(VLDL—C)19.2±9.6,高密度脂蛋白胆固醇(HDL—C)48.9±11.4,总胆固醇(T—C)169.4±34.3。HDl—C/T—C(％)30.64±7.42,LDL—C/HDL—C2.18±0.97,VLDL—C/HDL—C0.42±0.26。 冠心病、高血压、脑动脉硬化病人的T—C、LDI—C、VLDL—C水平及VLDL—C/HDL—C、LDL—C/HDL—C比值均明显地高于健康人,具有极显著意义(P<0.01),但HCL—C水平和HDL—C/T—C(％)较健康人降低(P<0.01)。因此认为,测定血清脂蛋白组分胆固醇水平能获得用于辅助诊断冠心病,高血压、脑动脉硬化及疗效观察的重要指标。
This article reports the serum cholesterol levels of 218 healthy individuals (81 males, 137 and 90-90 years of age) using agarose gel electrophoresis. Results: Low-density lipoprotein cholesterol (LDL-C) 100.2 ± 24.4, very low 19.2 ± 9.6 of density lipoprotein cholesterol (VLDL-C), 48.9 ± 11.4 of high-density lipoprotein cholesterol (HDL-C) and 169.4 ± 34.3 of total cholesterol (T-C) HDL-C / T-C (%) 30.64 ± 7.42, LDL-C / HDL-C2.18 ± 0.97, VLDL-C / HDL-C 0.42 ± 0.26. The levels of T-C, LDI-C and VLDL-C and the ratios of VLDL-C / HDL-C and LDL-C / HDL-C in patients with coronary heart disease, hypertension and cerebral arteriosclerosis were significantly higher than those in healthy people (P <0.01), but the levels of HCL-C and HDL-C / T-C (%) were lower than those in healthy subjects (P <0.01). Therefore, the determination of serum cholesterol levels of serum lipoprotein components can be used to help diagnose coronary heart disease, hypertension, cerebral arteriosclerosis and the important indicators of observation.