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以DMF为溶剂,卤代烃(RX)与丙二酸二乙酯(1)在氢氧化铯(CsOH)催化下合成了α-烷基丙二酸二乙酯(2)和α,α-二烷基丙二酸二乙酯(3)。当r[n(RX)∶n(CsOH)∶n(1)]=1.0∶1.0∶1.0时,2为主要产物;当r=2.2∶2.0∶1.0时,3为主要产物。化合物的结构经1HNMR和MS表征。
Diethyl α-alkylmalonate (2) and α, α-dimethylformamide were synthesized under the catalysis of cesium hydroxide (CsOH) using DMF as solvent and halogenated hydrocarbon (RX) Dialkyl dialkyl malonate (3). 2 is the major product when r [n (RX): n (CsOH): n (1)] = 1.0: 1.0: 1.0 and 3 is the major product when r = 2.2: 2.0: 1.0. The structure of the compound was characterized by 1HNMR and MS.