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2-甲基 - 3-氟 - 4,6-二溴苯甲酸 (1 )是合成一些氟喹诺酮抗菌药的重要原料 [1]。本文以 2 -甲基 - 3-硝基苯甲酸 (2 )为原料 ,参考文献 [2 ]对 1的合成进行研究 ,其合成路线如下COOHCH3NO2CH3OHSOCl2COOCH3CH3NO2Fe/ HClCOOCH3CH3NH2Br2 / HClBr COOCH3CH3NH2Br2
2-methyl-3-fluoro-4,6-dibromobenzoic acid (1) is an important raw material for the synthesis of some fluoroquinolone antibacterials [1]. In this paper, 2 - methyl - 3 - nitrobenzoic acid (2) as the raw material, reference [2] on the synthesis of 1, the synthetic route is as follows COOHCH3NO2CH3OHSOCl2COOCH3CH3NO2Fe / HClCOOCH3CH3NH2Br2 / HClBr COOCH3CH3NH2Br2