论文部分内容阅读
目的探讨丙种球蛋白冲击治疗儿童腹型过敏性紫癜的短期疗效。方法 72例腹型过敏性紫癜患儿,按照随机数字表法分为观察组及对照组,各36例。观察组采用丙种球蛋白冲击治疗,对照组采用甲强龙冲击治疗,对比两组患儿的短期疗效。结果观察组皮损皮损开始消失时间、腹痛缓解时间、血便消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组血沉、血清免疫球蛋白(Ig)A、丙二醇、对氧磷酶水平均较本组治疗前改善,且观察组改善程度优于对照组,差异均有统计学意义(P<0.05)。两组患儿均未发生明显的药物不良反应。随访6~12个月,观察组复发率为5.6%(2/36),低于对照组的27.8%(10/36),差异有统计学意义(χ2=6.40,P<0.05)。结论丙种球蛋白冲击疗法可改善儿童过敏性紫癜血凝状态、降低抗体的产生,并抑制机体过氧化性损伤,从而加速症状缓解,降低复发率。
Objective To investigate the short-term effect of gamma globulin shock on children with abdominal Henoch-Schonlein purpura. Methods 72 cases of children with atypic purpura were randomly divided into observation group and control group according to the random number table method, 36 cases in each group. The observation group treated with gamma globulin shock, the control group treated with methylprednisolone, compared the short-term efficacy of two groups of children. Results The skin lesions in the observation group began to disappear, the pain relief time and the disappearance of bloody stools were shorter than those in the control group (P <0.05). After treatment, the levels of ESR, serum immunoglobulin (A), propylene glycol and paraoxonase in both groups were improved compared with before treatment, and the improvement in observation group was better than that in control group (P < 0.05). No significant adverse drug reactions occurred in both groups. The follow-up ranged from 6 to 12 months. The recurrence rate was 5.6% (2/36) in the observation group and 27.8% (10/36) in the control group. The difference was statistically significant (χ2 = 6.40, P <0.05). Conclusion The gamma globulin shock therapy can improve the hemagglutination status of children with Henoch-Schonlein purpura, reduce the production of antibodies, and inhibit the peroxidative injury of the body, so as to accelerate the relief of symptoms and reduce the recurrence rate.