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目的:探讨血脂异常对血清丙氨酸氨基转移酶(ALT)及γ-谷氨酰转移酶(GGT)活力的影响。方法:选择2011年6月-2013年5月1320名健康体检成年人。按性别及血脂分层分为血脂正常组和异常组两组,比较两组间血清ALT、GGT活力。结果:同性别总胆固醇(TC)的不同层次各组间ALT、GGT活力存在差异(P<0.05),各组间的ALT、GGT活力均为升高组>边缘升高组>正常组;同性别组的甘油三酯(TG)在升高组与正常组及边缘升高组问的ALT、GGT活力均存在差异(P<0.05);TC、TG异常组的ALT、GGT升高检出率明显高于正常组(P<0.05)。结论:血脂异常并存肝细胞损害及肝功能异常,对血脂异常升高者,应及早测定ALT及GGT,对脂肪性肝病的早期预防和治疗干预有一定的临床指导意义。
Objective: To investigate the effect of dyslipidemia on serum alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) activity. Methods: Select June 2011 - May 2013 1320 health examination adults. According to gender and lipid profile, the patients were divided into two groups: normal blood lipid group and abnormal blood lipid group. The serum ALT and GGT activities were compared between the two groups. Results: There were differences in ALT and GGT activities between groups at different levels of the same sex total cholesterol (TC) (P <0.05). The activities of ALT and GGT in all groups were increased> increased margin> normal group. There was significant difference in ALT and GGT activity between the TG and TG groups (P <0.05). The detection rate of ALT and GGT in TC and TG abnormal group Significantly higher than the normal group (P <0.05). CONCLUSIONS: Dyslipidemia is associated with hepatocellular damage and abnormal liver function. ALT and GGT should be detected as early as possible in patients with elevated serum lipids, which may be of clinical significance for early prevention and treatment of fatty liver disease.