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锌作为人体的一种重要必需金属离子,近来已引起注意。有80多种金属酶必需有锌离子始能发挥功能。醛缩酶、脱氢酶、肽酶和磷酸酶都含有锌;锌对蛋白质的生物合成和分解代谢具有重要作用。除这些生化、生理功能之外,已证实锌还具有胃、肝保护作用,其作用机制与锌的膜稳定作用和清除自由基的特性有关。谷光甘肽(glutathione)的作用锌对质膜稳定性的影响谷光甘肽是动物细胞特别是生物膜上最重要的巯基(SH)化合物之一,有巯基还原态(GSH)和氧化态(GSSG)两种形式。由于细胞内谷光甘肽还原酶和辅酶Ⅱ(NADPH)对巯基还原状态的影响,几乎所有谷光甘肽均为GSH。锌对维持GSH的水平有重要作用,其依据是锌可抑制肝细胞微粒体中NADPH氧化酶的活性,从而维持NADPH
Zinc, an important essential metal ion of the human body, has recently attracted attention. More than 80 kinds of metal enzymes must be able to function with zinc ions. Aldolase, dehydrogenase, peptidase and phosphatase all contain zinc; zinc plays an important role in protein biosynthesis and catabolism. In addition to these biochemical and physiological functions, zinc has also been shown to have a protective effect on the stomach and the liver. Its mechanism of action is related to the membrane stabilizing effect of zinc and the scavenging of free radical properties. Effects of Glutathione on the Stability of Plasma Membrane Glutamate is one of the most important sulfhydryl (SH) compounds on animal cells, especially on biofilms. It has both thiol-reduced (GSH) and oxidized (GSSG) Two forms. Almost all glutathione is GSH due to the effects of intracellular glutathione reductase and coenzyme II (NADPH) on the thiol reduction state. Zinc plays an important role in maintaining GSH levels on the basis that zinc inhibits NADPH oxidase activity in liver cell microsomes and thus maintains NADPH