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用组织化学及免疫组织化学方法检测２２例肝细胞不典型增生（ＬＣＤ）的γ－ＧＴ酶、甲胎蛋白（ＡＦＰ）、癌胚抗原（ＣＥＡ）的表达情况。其中１７例同时应用显微分光光度计检测其ＤＮＡ含量，以探讨其与上述３种肿瘤标志表达情况的关系。结果显示：ＬＣＤ的肿瘤标志表达既不同于非不典型增生之肝细胞也不同于肝细胞癌，其ＤＮＡ含量均值及倍体分布介于癌与非不典型增生肝细胞之间（ｐ＜０．０５～０．０１）。ＤＮＡ的改变与肿瘤标志的表达存在一定的内在联系。提示ＬＣＤ是一类轻重不同的增生性病变，其中含非整倍体细胞较多的或许是肝细胞癌的癌前病变。
The expression of γ-GTase, alpha-fetoprotein (AFP), and carcinoembryonic antigen (CEA) in 22 cases of atypical hyperplasia (LCD) was detected by histochemical and immunohistochemical methods. In 17 cases, the DNA content was detected by microscopy spectrophotometer at the same time to investigate its relationship with the above three tumor marker expressions. The results showed that the expression of tumor markers on LCD was different from that of non-atypical hyperplasia and hepatocellular carcinoma. The average DNA content and ploidy distribution were between the cancer and non-atypical hyperplasia hepatocytes (p<0. 05-0.01). There is a certain intrinsic link between changes in DNA and the expression of tumor markers. Tip: LCD is a type of proliferative lesion with different severity, and it may be precancerous lesions of hepatocellular carcinoma that contain more aneuploid cells.