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1987年,Ashwell等发现激活诱导的细胞死亡(AICD)现象,即成熟的外周血淋巴细胞(PBLs)被抗原刺激活化后在抗原CD3/TCR单抗或植物血凝素(PHA)的再刺激下可发生凋亡。研究发现20%~30%的反应性T细胞在同种抗原的再刺激下发生凋亡,产生典型的形态学与分子生物学特征。AICD现象被称作
In 1987, Ashwell et al. Found that Activated Induced Cell Death (AICD) phenomenon, when mature peripheral blood lymphocytes (PBLs) were activated by antigen stimulation and then restimulated with antigen CD3 / TCR monoclonal antibody or phytohemagglutinin (PHA) Apoptosis can occur. The study found that 20% to 30% of reactive T cells under the same antigen in the restimulation of apoptosis, resulting in typical morphological and molecular biology. AICD phenomenon is called