论文部分内容阅读
目的众所周知,高血压前期与心血管疾病和胰岛素抵抗是相关的。然而,高血压前期是不是糖尿病的一个危险因素,却不得而知。本文主要研究高血压前期是否是2型糖尿病发生的一个危险因素。方法参与圣安东尼奥心脏研究的人群均是既往无糖尿病史且血压正常、仅在调查时偶然被诊断的新发糖尿病患者。共2767例,年龄是25～65岁,平均随访年限是7.8年。结果新发糖尿病患者有12.4%处于高血压前期阶段,5.6%是血压正常。校正年龄、性别和种族因素后,高血压前期发生糖尿病的相对危险度是血压正常者的2.21倍(95%可信区间1.63～2.98)。进一步校正BMI、糖耐量减低、HOMA-IR、HOMA-βC和糖尿病家族史后,发现高血压前期和糖尿病的发生无相关性(相对危险度是1.42,95%可信区间0.99～2.02)。结论高血压前期可增加糖尿病的发生风险。机制可能是高血压前期和胰岛素抵抗综合征相关。
It is well known that prehypertension is associated with cardiovascular disease and insulin resistance. However, prehypertension is not a risk factor for diabetes, it is unknown. This article focuses on whether prehypertension is a risk factor for type 2 diabetes. Methods Participants in the San Antonio Heart Study were all newly diagnosed diabetics with no previous history of diabetes mellitus and normotensive subjects who were only occasionally diagnosed at the time of the survey. A total of 2767 cases, the age is 25 to 65 years old, the average follow-up period is 7.8 years. Results 12.4% of new-onset diabetic patients were in the prehypertensive stage and 5.6% were normotensive. After adjusting for age, gender and ethnicity, the relative risk of developing prehypertension was 2.21 times greater than those with normotensive (95% confidence interval 1.63-2.98). After further adjustment for BMI, impaired glucose tolerance, HOMA-IR, HOMA-βC, and family history of diabetes, no association was found between prehypertension and diabetes (relative risk 1.42, 95% confidence interval 0.99 to 2.02). Conclusion Prehypertension can increase the risk of diabetes. Mechanisms may be related to prehypertension and insulin resistance syndrome.