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通过一定剂量的卡那霉素与不同剂量的利尿酸钠联合应用，使猫在短时间内出现不同程度的听力损失。将１９只听力正常猫随机分成三组。第一组：肌注卡那霉素（３００ｍｇ／ｋｇ）半小时后，以１ｍｇ／ｍｉｎ的速度静脉推注利尿酸钠，同时记录ＡＢＲ以连续观察听力情况，当阈值开始提高时，停止用药。第二、三组：减少利尿酸钠用量，分别为第一组的１／３、２／３，其余步骤同第一组。结果显示：第一组在短时间内出现严重的不可逆的听力损失；第二、第三组出现轻、中度听力损失。这为听力学基础和临床研究快速制备了不同程度耳聋的动物模型。
Through a certain amount of kanamycin and different doses of sodium urate, the cat in a short period of time to varying degrees of hearing loss. Nineteen normal hearing cats were randomly divided into three groups. The first group: intramuscular injection of kanamycin (300mg / kg) half an hour later, the rate of 1mg / min intravenous infusion of sodium urate, while recording ABR continuous observation of hearing, when the threshold began to increase, stop the medication. The second and third groups: reduce the dosage of sodium urate, respectively, the first group of 1/3, 2/3, the remaining steps with the first group. The results showed that the first group had serious irreversible hearing loss in a short time, and the second and third group had mild to moderate hearing loss. This rapid preparation of different degrees of deafness for the basic and clinical audiology animal model.