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目的探讨老年脑梗死患者高压氧(HBO)治疗前后体内可溶性细胞间粘附分子1(sICAM1)表达水平的变化及其与疾病变化相关性。方法选择老年脑梗死患者及老年健康体检者各20例,通过ELISA法分别检测其血清sICAM1水平并进行组间比较。结果脑梗死组sICAM1值高于正常对照组,其组间差别具有统计学意义(P<0.01)。HBO治疗后脑梗死组sICAM1水平显著降低(P<0.01),与正常对照组比较差别无统计学意义(P>0.05)。结论HBO可明显抑制老年脑梗死患者体内sICAM1的表达。
Objective To investigate the changes of soluble intercellular adhesion molecule-1 (sICAM1) in patients with cerebral infarction before and after hyperbaric oxygen therapy (HBO) and its relationship with disease changes. Methods 20 elderly patients with cerebral infarction and 20 healthy elderly subjects were selected and their levels of serum sICAM1 were detected by ELISA and compared between groups. Results The sICAM1 level in cerebral infarction group was higher than that in normal control group, and the difference between the two groups was statistically significant (P <0.01). The level of sICAM1 in HBO-treated group was significantly lower than that in normal control group (P <0.01). There was no significant difference between the two groups (P> 0.05). Conclusion HBO can significantly inhibit the expression of sICAM1 in elderly patients with cerebral infarction.