目的:探讨营养状态评价指标与临床病理预后信息的关系，明确营养状态评价对Ⅰ~Ⅳ期胃癌胃全切术后的肿瘤复发和长期生存的预测价值。方法:回顾性分析2001年1月1日至2015年12月30日在北京大学第一医院住院治疗的302例接受胃全切的胃癌患者的临床数据，收集其术前临床特征和血液学检查结果，计算患者营养状态评价数据，电话随访患者复发和生存时间，计算无病生存期和总生存期，进行营养状态评价和临床资料与生存信息的数据分析。结果:302例接受胃全切的胃癌患者的临床数据分析提示，营养状态与肿瘤患者分期相关，分期越晚越需要营养治疗介入。单因素分析表明，TNM分期Ⅲ+Ⅳ期（n HR=4.417， 95%n CI：2.483~6.351；n P=0.029）、患者年龄≥65岁（n HR=2.217， 95%n CI：0.522~3.912；n P =0.038）、淋巴结转移（n HR=2.517， 95%n CI：0.516~4.518；n P=0.036）、肿瘤低分化（n HR=3.626， 95%n CI：0.721~6.531；n P =0.021）和低预后营养指数（PNI）（n HR=2.612， 95%n CI： 0.712~4.512； n P=0.029）是预后不良的重要危险因素。在多因素分析中，TNM分期Ⅲ+Ⅳ期（n HR=3.821， 95%n CI：1.923~5.719； n P=0.014）、患者年龄≥65岁（n HR=1.168， 95%n CI：0.321~2.015；n P =0.036）和低PNI（n HR=2.435， 95%n CI：1.024~3.846；n P =0.039）与不良的生存时间具有独立相关性；当将年龄作为分层因素时，控制营养状态评分（CONUT）在≥65岁胃癌患者胃全切术后复发和生存关联的分析比较中，CONUT高（>3）组的无病生存期为25.2个月，CONUT低（≤3）组为30.9个月，两者差异有统计学意义（χ2=3.763，n P=0.029）；CONUT高（>3）组的总生存期为30.3个月，CONUT低（≤3）组为34.5个月，两者差异有统计学意义（χ2=4.924，n P=0.042）。n 结论:营养状态评价是胃癌患者胃全切术后生存相关预后指标，是预测老年胃癌根治性胃全切术后无病生存和总体生存的独立危险因素。“,”Objective:To evaluate the effect of nutritional status on clinical and pathological data for stage Ⅰ-Ⅳ gastric cancer patients from the cancer survival investigation information.Methods:A database of 302 consecutive gastric cancer patients underwent radical gastrectomy was enrolled in this study. The clinical and pathological information of them were corrected and the relationship between the nutritional index and the patients survival time were analyzed by a Cox regression model.Results:The clinical data analysis of 302 patients with gastric cancer who received total gastric resection indicated that the nutritional status was related to the stage of tumor patients, suggesting that the later the stage was, the more necessary the nutritional therapy intervention was. Univariate analysis showed that Ⅲ+Ⅳ of TNM staging (n HR=4.417, 95%n CI:2.483-6.351; n P =0.029), patient age of 65 and above (n HR=2.217, 95%n CI:0.522-3.912;n P =0.038), lymph node metastasis positive (n HR=2.517, 95%n CI:0.516-4.518; n P=0.036), poor tumor differentiation (n HR=3.626, 95%n CI:0.721-6.531; n P =0.021) and low PNI (n HR=2.612, 95%n CI: 0.712-4.512; n P =0.029) is an important risk factor for poor prognosis. In the multivariate analysis, Ⅲ+Ⅳ of TNM staging (n HR=3.821, 95%n CI:1.923-5.719; n P =0.014), patient age of 65 and above (n HR=1.168, 95%n CI:0.321-2.015; n P =0.036) and low PNI (n HR=2.435, 95%n CI:1.024-3.846; n P =0.039) was independently correlated with poor survival time; When age was used as a stratification factor, the correlation between CONUT recurrence and survival in patients with gastric cancer ≥65 years old after total gastric resection was analyzed and compared. For disease-free survival, the CONUT high group (>3) was 25.2 months, while the CONUT low group (≤3) was 30.9 months, (χn 2=3.763,n P=0.029), showing a significant difference. For the overall survival, the CONUT high(>3) group was 30.3 months, compared with the CONUT low(≤3) group at 34.5 months, (χn 2=4.924,n P=0.042), and the difference was also statistically significant.n Conclusions:High controlling nutritional status is an independent risk factor associated with poor gastric cancer survival and it is an independent risk factor in predicting overall survival (OS) in elderly (≥65) gastric cancer after radical gastrectomy.